| Grant number: | 00/03545-8 |
| Support Opportunities: | Scholarships abroad - Research |
| Start date: | August 21, 2000 |
| End date: | August 20, 2001 |
| Field of knowledge: | Biological Sciences - Biophysics - Molecular Biophysics |
| Principal Investigator: | Carlos Roberto Benatti |
| Grantee: | Carlos Roberto Benatti |
| Host Investigator: | Richard M. Epand |
| Host Institution: | Pessoa Física |
| Institution abroad: | McMaster University, Canada |
Abstract Cholesterol is a major component of mammalian plasma membranes. It has a profound effect on the physical properties of membranes. The possible role of cholesterol in lipofection has not been investigated. It is known that several negatively charged amphiphiles affect the solubility of cholesterol in membranes and "a priori" the cationic amphiphiles used in lipofection may also affect cholesterol solubility in membranes. The cholesterol may have different effects on the cell. One of the consequences of cationic amphiphiles interacting with biological membranes may be that the anionic lipids in these membranes compete with DNA for interaction with the cationic amphiphiles. We will determine what the lipid dependence. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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