Assessing the impact of individual frailty in vaccine response on the efficacy of BCG

• Grant number: 00/01347-4
• Support Opportunities: Scholarships abroad - Research
• Effective date (Start): May 01, 2000
• Effective date (End): May 31, 2000
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: Eduardo Massad
• Grantee: Eduardo Massad
• Host Investigator: Peter G Smith
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Research place: London School of Hygiene and Tropical Medicine, England

Abstract

A central question in epidemiology is how heterogeneity, in its different manifestations, influences the dynamics and intensity of infections. The individual differences have been named \QTR{it}{frailty} in the demography literature in the context of susceptibility to death. In this project we propose an epidemic model, taking into account the phenomenon of frailty in the vaccination rate, and analyze its impact on the observable rates. We are particularly interested in the impact of frailty on the vaccination response in order to improve the assessment of efficacy to BCG. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

EDUARDO MASSAD; MARCELO NASCIMENTO BURATTINI; FRANCISCO ANTONIO BEZERRA COUTINHO; LUIZ FERNANDES LOPEZ. Dengue e risco da reintrodução da febre amarela urbana no Estado de São Paulo. Revista de Saúde Pública, v. 37, n. 4, p. 477-484, 2003-08-00. (00/01347-4)