Effect of alpha-tocopherol and hypertonic sodium chloride dextran in the attenuation of the injuries of ischemia and reperfusion in splanchnic organs

• Grant number: 93/04242-3
• Support Opportunities: Scholarships abroad - Research
• Start date: May 01, 1994
• End date: March 06, 1995
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Winston Bonetti Yoshida
• Grantee: Winston Bonetti Yoshida
• Host Investigator: Herbert Dardik
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Institution abroad: Englewood Hospital and Medical Center, United States

Abstract

Ischemia and reperfusion of splanchnic organs can result in a severe form of circulatory collapse known as splanchnic artery occlusion shock, probably related to increased capillary permeability and oxygen-derived free radicals accumulation. The aim of the present study is at verifying the role of the scavenger alpha-tocopherol and hypertonic saline Dextra in the attenuation of injuries of ischemia and reperfusion in splanchnic organs in a rat model. (AU)