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| Author(s): |
Phablo Sávio Abreu Teixeira
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2014-12-12 |
| Examining board members: |
Rui Curi;
Carla Roberta de Oliveira Carvalho;
Luis Marcelo Inaco Cirino;
Luiz Antonio Gioielli;
Antonio Carlos Oliveira
|
| Advisor: | Rui Curi; Sandro Massao Hirabara |
| Abstract | |
The effects of linoleic and oleic acids on regeneration of lacerated gastrocnemius muscle in rats and on cultured myoblasts, myotubes and fibroblasts were examined. There was incomplete regeneration and partial recovery of the contractile function of the injured muscle. Linoleic acid reduced the mass, contratile activity and cross-sectional area of the fibers, raised the fibrous area and reduced the expression of PCNA, collagen and fibronectin in fibroblasts. Oleic acid abolished the changes in contratile activity and the increase in the fibrous area, raised the expressions of MyoD in myoblasts, desmin in myotubes and inhibited the expressions of PCNA, collagen and fibronectin in fibroblasts. Linoleic acid impaired regeneration whereas oleic acid optimized the regenerative capacity and contractile function of the injured muscle. (AU) | |
| FAPESP's process: | 11/06815-0 - Myogenesis and regeneration of skeletal muscle: possible modulation by linoleic acid |
| Grantee: | Phablo Sávio Abreu Teixeira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |