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Molecular factors involved in the metabolic changes during pregnancy: role of SOCS3.

Full text
Author(s):
Thais Tessari Zampieri
Total Authors: 1
Document type: Doctoral Thesis
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas
Defense date:
Examining board members:
José Donato Júnior; Jackson Cioni Bittencourt; Patrícia de Oliveira Prada; Sandra Maria Lima Ribeiro; Silvana Auxiliadora Bordin da Silva
Advisor: José Donato Júnior
Abstract

About half of brazilian adults are obese or overweight, and excess weight gain during pregnancy among the most important risk factors for the development of obesity in women. Besides the excessive weight gain during pregnancy, gestational diabetes is another metabolic problem often faced by pregnant women. The present work we demonstrated that the expression of SOCS3 in LepR expressing cells has proved essential to fully cause hyperphagia due to pregnancy and lactation that, as a consequence, reduces weight gain and fat accumulation during these periods, ensuring a lower weight retention postpartum. Finally, the conditional deletion of SOCS3 significantly improves glucose homeostasis during pregnant females protecting against the development of gestational diabetes. (AU)

FAPESP's process: 12/15517-6 - Involvment of molecular factors in metabolic changes during pregnancy: role of SOCS3
Grantee:Thais Tessari Zampieri
Support type: Scholarships in Brazil - Doctorate