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| Author(s): |
Cleyton Roberto Sobrinho
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2015-12-03 |
| Examining board members: |
Thiago dos Santos Moreira;
Vagner Roberto Antunes;
Luiz Guilherme de Siqueira Branco;
Newton Sabino Canteras;
Daniel Breseghello Zoccal
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| Advisor: | Thiago dos Santos Moreira |
| Abstract | |
Central (CC) and peripherals (PC) chemoreceptors are specialized cells to detect changes in CO2, O2 and H+, and produce adjustments in ventilation and blood pressure via the central nervous system. Here we evaluate the action of purinergic signaling in areas with this property (RTN, C1, commNTS, RPA) during the cardiorespiratory responses elicited by activation of chemoreceptors, and a possible role of astrocytes. We found evidence that P2 receptors modulate CC responses in RTN, while P2Y1 and glutamate receptors modulate PC responses in C1, and that the purinergic signaling in the RPa and commNTS region does not contribute to CC responses. The pharmacological manipulation of the RTN astrocytes, but not commNTS or RPa, with fluorocitrate produces respiratory changes via P2 receptors. Our findings show the importance and contribute to discrimination of the mechanisms of purinergic signaling in the rostral ventrolateral medulla during CC and PC activation. (AU) | |
| FAPESP's process: | 11/13462-7 - The interaction between retrotrapezoid nucleus astrocytes and neurons on respiratory responses promoted by central chemoreflex activation |
| Grantee: | Cleyton Roberto Sobrinho |
| Support Opportunities: | Scholarships in Brazil - Doctorate |