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Effect of interaction of Angiotensin II and AT1 receptor, or endothelin 3 and ETA and ETB receptors on renal function and morphology in rats.

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Author(s):
Fernando Augusto Malavazzi Casare
Total Authors: 1
Document type: Doctoral Thesis
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:
Examining board members:
Maria Oliveira de Souza; Fernanda Barrinha Fernandes; Claudia Maria de Barros Helou; Gerhard Malnic; Rildo Aparecido Volpini
Advisor: Maria Oliveira de Souza
Abstract

To evaluate the chronic effects of angiotensin II (Ang II) and /or losartan or endothelin-3 (ET-3) and /or atrasentan or BQ788, Wistar rats were organized as: control, treated with Ang II, or ET-3 for 42 days, losartan-treated, co-treated with Ang II and losartan. Treated with ET-3, treated with BQ788 or atrasentan, co-treated with ET-3 and antagonists. Were evaluated: blood pressure, plasma and intrarenal concentrations of Angs and ETs, protein expression, renal morphology and function. Ang II induced hypertension, increased plasma levels of ETs and Angs; increased mRNA for renin; induced glomerular injury and renal arterioles remodeling. Treatment with losartan restored most of the changes induced by Ang II. ET-3 induced hypertension, glomerular injury, renal dysfunction and increased intrarenal mRNA for SRA components. The ETA receptor blockage reverted the ET-3 effects on hypertension, while ETB blockage reverted renal parameters. Our results suggest a crosstalk of renin-angiotensin and endothelin systems, inducing renal structural and functional changes. (AU)

FAPESP's process: 11/14022-0 - Effect of interaction between renin-angiotensin-aldosterone system and endothelin 1 and 3 on renal function
Grantee:Fernando Augusto Malavazzi Casare
Support Opportunities: Scholarships in Brazil - Doctorate