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| Author(s): |
Alexandre Gomes Pinto
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Instituto de Física Gleb Wataghin |
| Defense date: | 2016-02-26 |
| Examining board members: |
Rickson Coelho Mesquita;
Oswaldo Baffa Baffa Filho;
Gabriela Castellano
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| Advisor: | Rickson Coelho Mesquita |
| Abstract | |
The neurovascular-metabolic coupling, or simply neurovascular coupling, is the connection between the neuronal activity and the cerebral metabolic and vascular activities. During the execution of tasks, there is a demand of cellular energy to supply the cerebral tissue. This demand must be balanced by a boost in the oxygen and metabolites amounts provided to the cerebral regions responsible for the execution of the tasks. This balance is characterized by a neurovascular coupling, associated with vasodilation and the control of blood flow, and by a neurometabolic coupling, associated with the energy demand and the oxygen and glucose consumption by the cerebral tissue. The main objective of this project was to study the neurovascular-metabolic coupling in healthy, adult humans during a functional cortical activation protocol, through simultaneous measurements of electroencephalography (EEG) and diffuse optical spectroscopy (DOS), during an experiment of functional motor activation. The connection between the electrophysiological and hemodynamic data was made through a dynamic model based on the transfer function formalism. We studied vascular and metabolic biophysical models that helped us to characterize the coupling from a macroscopic approach. An experiment with simultaneous measurements of EEG and DOS was performed on a single subject, and the results suggest conformity with the predicted behavior in literature. With this single experiment, it was possible to validate our simultaneous electroencephalography and diffuse optical spectroscopy protocol to get a quantitative characterization of the neurovascular coupling. This is a pioneering project when it comes to establishing a systematic way to characterize the neurovascular coupling in humans (AU) | |
| FAPESP's process: | 13/21764-9 - Characterization of neurovascular-metabolic coupling in humans with diffuse optical techniques |
| Grantee: | Alexandre Gomes Pinto |
| Support Opportunities: | Scholarships in Brazil - Master |