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| Author(s): |
Ana Paula Cremasco Takano
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2016-04-25 |
| Examining board members: |
Maria Luiza Morais Barreto de Chaves;
Ronaldo de Carvalho Araújo;
Niels Olsen Saraiva Câmara;
Gisele Giannocco;
Carolina Demarchi Munhoz
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| Advisor: | Maria Luiza Morais Barreto de Chaves |
| Abstract | |
The present study evaluated inflammation related aspects in cardiac hypertrophy induced by thyroid hormones (TH) and the possible involvement of the renin-angiotensin system (RAS) in this process, by using in vivo and in vitro analysis. The results showed alterations in circulating and cardiac cytokines from TH treated animals. The expression of S100A8 and MyD88 were increased in the heart of hyperthyroid rats and in cultured cardiomyocytes stimulated with TH. S100A8 and MyD88 mediated the nuclear factor NF-κB activation by TH and these factors presented crucial role to the hypertrophic growth of TH-treated cardiomyocytes. Finally, the action of TH on S100A8 and NF-κB expression was mediated by RAS. These data contribute to the knowledge of molecular basis of TH action and the relationship between TH and RAS in cardiac hypertrophy. (AU) | |
| FAPESP's process: | 11/23352-4 - Association between inflammation-related pathways and cardiac hypertrophy induced by thyroid hormone. Role of the Renin-Angiotensin System |
| Grantee: | Ana Paula Cremasco Takano |
| Support Opportunities: | Scholarships in Brazil - Doctorate |