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| Author(s): |
Aldair de França Neto
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2016-06-29 |
| Examining board members: |
Luciana Venturini Rossoni;
Eliana Hiromi Akamine;
Lusiane Maria Bendhack;
Maria Luiza Morais Barreto de Chaves;
Fernanda Roberta Roque Redondo
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| Advisor: | Luciana Venturini Rossoni |
| Abstract | |
The chronic administration of ouabain (OUA) induces hypertension in rats, functional and structural alterations in mesenteric resistance arteries (MRA). It is well known that OUA-induced hypertension is blocked by AT1 receptor antagonism and the COX-2 inhibition. However, the participation of these pathways in MRA remodeling in this model of hypertension remains unknown. This study aimed to investigate the role of the renin angiotensin system (RAS) and COX pathways on MRA remodeling induced by OUA. In AMR from OUA rats, RAS and COX-2 participate in the pressor response, the inward hypotrophic remodeling and stiffness. These adjustments are the result of oxidative stressand increasing collagen deposition in the vascular wall stimulated by the OUA ability to stimulate the activation of AT1 receptor and COX-2. (AU) | |
| FAPESP's process: | 12/00217-7 - Study of mechanisms involved in the remodeling of resistance arteries from ouabain hypertensive rats |
| Grantee: | Aldair de França Neto |
| Support Opportunities: | Scholarships in Brazil - Doctorate |