High blood pressure and autonomic dysfunction induced by high-fat diet: role of CART and inflammatory factors in central autonomic network.

Author(s)

Laiali Jurdi El Chaar

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2016-06-27

Examining board members

Vagner Roberto Antunes; Ruy Ribeiro de Campos Junior; Kátia de Angelis Lobo D'Avila; William Tadeu Lara Festuccia; Angelina Zanesco

• Advisor: Vagner Roberto Antunes

Abstract

Obesity is a risk factor for high blood pressure and the mechanisms involved in this disease are not fully clarified. C57BL/6J and transgenic mice with toll-like-NFκB receptor inflammatory- pathway deletion in neurons and glia were fed with high-fat diet (HL) for 8 or 15 weeks and assessed metabolic parameters, blood pressure, heart rate, autonomic nervous system activity, inflammatory factors and neuropeptides in the hypothalamus and brainstem. The HL mice developed hypertension accompanied with autonomic dysfunction and increased CART in DMH. Transgenic animals when submitted to HL diet developed obesity, but not showed high blood pressure and autonomic dysfunction. In addition, HL animals had increased CCL5 mRNA in hypothalamus, CD86 mRNA in brainstem and micróglia density in caudal NTS. The results suggest new mechanisms for hypertension and autonomic dysfunction secondary to intake of high-fat diet by showing CART role in DMH and the involvement of the inflammatory pathway TLR-NFκB in neurons and glia. (AU)

• FAPESP's process: 11/13563-8 - Obesogenic diet and inflammatory process in the brainstem and its interaction with the autonomic nervous system and the arterial pressure
• Grantee: Laiali Jurdi El Chaar
• Support Opportunities: Scholarships in Brazil - Doctorate