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| Author(s): |
Marcos Vinicius da Silva
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2016-07-07 |
| Examining board members: |
Cecilia Helena de Azevedo Gouveia Ferreira;
Marise Lazaretti Castro;
Julio Cesar Batista Ferreira;
Katiucia Batista da Silva Paiva;
Rosa Maria Rodrigues Pereira
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| Advisor: | Cecilia Helena de Azevedo Gouveia Ferreira |
| Abstract | |
It is known that the thyroid hormone (TH) regulates the development and growth of bones. In the study, we investigated whether the HT interacts with the sympathetic nervous system (SNS) controlling bone longitudinal growth (CLO), and if this possible interaction depends on α2A-AR -/-. Therefore, we evaluated the effect of 30 days of hypothyroidism (HYPO) and hyperthyroidism (HYPER) and α2A-AR -/- 21 days old. We have seen that α2A-AR -/- animals have shorter femur, tibia, radius, humerus and L4 compared to Selv animals. As expected, the HYPO and HYPER damaged the CLO of these bones in Selv mice, however, the effect of HYPO was more deleterious. The morphology of the distal femur LE showed that α2A-AR -/- animals euthyroid (EUT) have clutter zones and changes in the number of chondrocytes and Hypothyroidism most harmful treatment. Data from this study suggest that PTHrP pathways / Ihh and IGF-1 / IGF-1R can be SNS convergence and HT pathways in the regulation of the CO morphophysiology involving the α2A-AR. It was observed that α2A-AR -/- animals show changes in trabecular bone with augmentation with the hipotireoismo. Furthermore, α2A-AR-/- animals show changes trabecular connectivity. These findings suggest that the SNS and interacts the HT dependent α2A-AR. (AU) | |
| FAPESP's process: | 12/11858-3 - Evaluation of the interaction of thyroid hormone with the sympathetic nervous system, via alpha-2 adrenergic receptors, in the regulation of bone growth and maturation |
| Grantee: | Marcos Vinicius da Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate |