Development of microreactor for bioresorbable polymer synthesis (PLLA) used as biomedical implants

Author(s)

Milena Savioli Lopes

• Document type: Doctoral Thesis
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Química
• Defense date: 2014-11-18

Examining board members

Rubens Maciel Filho; Norberto Aranha; Cecília Amélia de Carvalho Zavaglia; Viktor Oswaldo Cárdenas Concha; Rodrigo Alvarenga Rezende

• Advisor: Rubens Maciel Filho

Abstract

Currently, the concept of sustainability has been gaining more space and with it the challenges of improving industrial processes. The use of microreactors emerges as an attractive and potential option to meet the diverse and growing environmental and economic requirements. Furthermore, the malfunction or loss of total or partial functions of an organ or tissue resulting from disease or trauma is a major concern and public health problems, achieving a significant number of people worldwide. Thus, the main objective of this thesis was the development, manufacture and evaluation of microreactor capable of performing the synthesis of polymerization of poly (L-lactic acid) (PLLA) used as biomedical implants. To fulfill this objective, it was necessary to separately evaluate the conditions of synthesis and routes of obtaining the PLLA. The route chosen for polymerization with microreactor to be developed was in direct polycondensation. The products were generated and characterized by different analysis techniques. The results showed similarity between the two products and their cytotoxic evaluation confirmed their application with biomaterial. It can be concluded that the idea of microreactor proposed has been presented with great potential in fulfilment of the polymerization of the PLLA by direct polycondensation of lactic acid (AU)

• FAPESP's process: 10/00046-2 - Development of microreactors for the synthesis of bioabsorbable polymers (PLA) used as biomedical implants
• Grantee: Milena Savioli Lopes
• Support Opportunities: Scholarships in Brazil - Doctorate