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| Author(s): |
Tábata Takahashi França
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2017-06-07 |
| Examining board members: |
Antonio Condino Neto;
Regiane Aparecida Cavinato;
Cristina Maria Kokron;
Sonia Jancar Negro
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| Advisor: | Antonio Condino Neto |
| Abstract | |
Recent studies have shown that neutrophil extracellular traps (NETs) release an structure able to annul virulence factors and destroying microorganisms. Patients with X-linked Hyper-IgM syndrome (X-HIGM), a rare immunodeficiency caused by mutations in the CD40 ligand (CD40L) gene, are highly susceptible to opportunistic infections caused by fungi. Since neutrophil responses are important to control fungal infection and studies that indicate the influence of CD40-CD40L interaction on granulopoiesis, we propose to investigate whether the susceptibility to infections in X-HIGM patients could be related to the failure in NET formation. The results indicate that X-HIGM patients present a failure in NET generation in a stimulus-dependent manner, likely related to incomplete neutrophil maturation. The study contributes to the advancement of knowledge on the immunopathology of CD40L deficiency and contributes to elucidate the mechanisms involved in the susceptibility to infections in X-HIGM patients. (AU) | |
| FAPESP's process: | 15/01699-3 - Assessment of neutrophil extracellular traps formation in CD40 ligand deficient patients and influence of in vitro treatment with interferon-gamma |
| Grantee: | Tábata Takahashi França |
| Support Opportunities: | Scholarships in Brazil - Master |