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| Author(s): |
Aline Arcanjo Gomes
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) |
| Defense date: | 2017-10-11 |
| Examining board members: |
Isabel de Camargo Neves Sacco;
Marcos Duarte;
Silvia Maria Amado João;
Luciano Luporini Menegaldo;
Márcia Nery
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| Advisor: | Isabel de Camargo Neves Sacco |
| Abstract | |
Muscle force estimation could support a better understanding of the mechanical and muscular strategies that diabetic patients adopt to preserve walking ability and to guarantee their independence as they deal with their neural and muscular impairments due to diabetes and neuropathy. Our aim was to estimate and compare the lower limb\'s muscle force distribution during gait in diabetic patients with and without diabetic neuropathy. Data from ground reaction force (AMTI OR61000 force plate at 100Hz) and three-dimensional kinematics of ankle, knee and hip (eight-camera Optitrack® at 100 Hz) of 10 neuropathic (DNG), 10 diabetic non-neuropathic (DG) and 10 healthy individuals (CG) were used as input variables for the musculoskeletal model gait 2392 (23 degrees of freedom and 92 musculoskeletal actuators) in the OpenSim software. The standard generic model was scaled to fit the anthropometry of each individual collected, prior to the execution of the simulations. The musculoskeletal model of neuropathic individuals presented maximum isometric force reduced in 30% for ankle extensors and 20% for ankle dorsiflexors to mimic the atrophy of ankle muscles due to diabetic neuropathy. The force time series of lower limb muscles were calculated using the static optimization procedure. The peak muscle forces were calculated during selected time bands of the gait cycle. The peak force was compared between groups using MANOVA for the flexor and extensor muscle groups of hip, knee and ankle joints followed by ANOVA and post-hoc of Newman-Keuls (p < 0.05). DNG showed higher knee flexors peak force (biceps femoris short head / p < 0,001, semitendinous / p < 0,001 and semimenbranous / p < 0,001) during push-off, compared to DG and CG. DNG also presented lower peak force for gastrocnemius medialis and soleus, as well as higher peak force for gastrocnemius lateralis compared to DG and CG in the same gait phase. DG exhibited lower peak force for the hip extensor muscles (semitendinous and semimembranous) in the final swing and hip abductor muscles during stance, as well as higher peak force for the knee extensor muscles (vastus medialis and lateralis / p=0,004) in the early stance compared to DNG and CG. Diabetic patients with and without neuropathy appear to adopt different muscle force distribution strategies in spite of the progressive worsening in their health condition. While reducing ankle extensor forces, DG increased knee extensor muscle forces at early stance and reduced the hamstrings force at the end of swing phase, whereas DNG increased the hamstrings muscle forces at push-off. A resistance training program for the proximal muscles related to the knee joint could be considered in a rehabilitation routine for diabetic patients. Other potential inclusions in rehabilitation protocols consist of gait retraining and practicing functional exercises focusing on the activation of the hamstring muscles (AU) | |
| FAPESP's process: | 13/20813-6 - Role of muscle activity in diabetic neuropathic gait pattern: a study by dynamic simulation |
| Grantee: | Aline Arcanjo Gomes |
| Support Opportunities: | Scholarships in Brazil - Doctorate |