Full text
| |
| Author(s): |
Katherine Garcia Ravelli
Total Authors: 1
|
| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2017-07-07 |
| Examining board members: |
Luiz Roberto Giorgetti de Britto;
Rosana Camarini;
Tania Marcourakis;
Carolina Demarchi Munhoz;
Rosana de Lima Pagano
|
| Advisor: | Luiz Roberto Giorgetti de Britto |
| Abstract | |
Alzheimer\'s disease (AD) has been linked to oxidative stress. The goal of this study was to investigate the involvement of NADPH oxidase 2 (nox2), an enzyme that produces reactive oxygen species, in memory, in AD-related proteins expression, inflammation and neuronal death in the hippocampus in the streptozotocin (STZ)-induced AD-like pathology by comparing the effects of that drug on mice lacking Nox2 and wild type (Wt) mice. Nox2 gene expression was increased in Wt mice after STZ injection. Moreover, these animals presented impairment in memory, increased phosphorylation of Tau and increased amyloid-β protein, neurofilaments, caspase-3 and astrocyte and microglial markers expression, in addition to increased inflammatory cytokines release after treatment. Nox2 depletion prevented these effects. The baseline IL-10 levels were found increased following Nox2 deletion, suggesting that this is one mechanism by which mice lacking Nox2 are protected against STZ-induced AD-like pathology. (AU) | |
| FAPESP's process: | 12/01444-7 - NADPH oxidase and Alzheimer's Disease |
| Grantee: | Katherine Garcia Ravelli |
| Support Opportunities: | Scholarships in Brazil - Doctorate |