Full text
| |
| Author(s): |
Thyego Mychell Moreira Santos
Total Authors: 1
|
| Document type: | Doctoral Thesis |
| Press: | Botucatu. 2018-08-06. |
| Institution: | Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu |
| Defense date: | 2018-06-29 |
| Advisor: | Ilda de Godoy |
| Abstract | |
Smoking is responsible for the largest number of preventable deaths in the world, and is related to the development of several diseases, mainly chronic obstructive pulmonary disease (COPD). Thus, the search for early biomarkers of such diseases becomes relevant for their identification and for successful therapy. The objectives of our study were to evaluate the concentration of heat shock protein 70 (HSP70), expression of the HSP70 gene, anti-HSP70 auto antibodies, the systemic inflammatory marker through cytokine interleukin-8 (IL-8) and CPR, immunological changes and DNA damage in peripheral blood of chronic asymptomatic smokers and non-smokers. Our results showed increased serum concentrations of HSP70, anti-HSP70, IL-8, CPR and neutrophils, and DNA damage in blood cells of smokers than in non-smokers. Therefore, cigarette smoking was confirmed as a noxious agent on physiological and molecular parameters associated with the risk for developing COPD and other lung diseases. Based on the data we suggest that HSP70 can be responsible for the increased levels of inflammatory cytokines, and consequently, the increased influx of neutrophils into the lungs and increased DNA damages e anti-HSP70 auto antibodies. (AU) | |
| FAPESP's process: | 14/17983-0 - Expression of Heat Shock Proteins 70 in tobacco users |
| Grantee: | Thyego Mychell Moreira Santos |
| Support Opportunities: | Scholarships in Brazil - Doctorate |