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| Author(s): |
Giovanna Rodrigues Melin
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Escola de Artes, Ciências e Humanidades (EACH) |
| Defense date: | 2013-08-23 |
| Examining board members: |
Silgia Aparecida da Costa;
Mauricio de Campos Araujo;
Rodrigo Cardoso de Oliveira
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| Advisor: | Silgia Aparecida da Costa |
| Abstract | |
Chitosan is a polysaccharide produced from chitin by deacetylation and has been studied for application as biomaterial for presenting characteristics, such as biocompatibility and antimicrobial atoxidade. The objective of this study was the development and characterization chemical, physical and biological of membranes based on chitosan and carboxymethylcellulose (CMC) for application in the biomedical area. Tests of resistance, water absorption capacity and mass loss in phosphate buffered saline (PBS) and artificial saliva, Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), bioactivity and cytotoxicity. The tests of cytotoxicity revealed that the membranes developed are non toxic and water absorption test the CMC increased significantly absorption capacity of membrane. The natural characteristics of the polymers were not changed, as observed on DSC and FTIR. With regard to the release of lysozyme, membranes CHI and CHI/CMC/CHI obtained better results in both the release and in the activity of the enzyme. The main applications of the membranes studied in the biomedical field are like bandages. (AU) | |
| FAPESP's process: | 11/04141-2 - Development of bandages based on natural polymers for medical applications |
| Grantee: | Giovanna Rodrigues Melin |
| Support Opportunities: | Scholarships in Brazil - Master |