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| Author(s): |
Alyne Santana Rosa
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2018-10-02 |
| Examining board members: |
Marucia Chacur;
Raquel Chacon Ruiz Martinez;
Maria Ines Nogueira;
Raquel Simoni Pires
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| Advisor: | Marucia Chacur |
| Abstract | |
Chronic musculoskeletal disorders are a public health problem due to its high prevalence, high economic cost and negative impact on patients and their relatives quality of life. Due to this, researchers have been studying muscle injury in animal models to better understand the mechanisms involved in the initiation and maintenance of musculoskeletal disturbs. To elucidate the nociceptive mechanisms involved in this process and seek for effective therapies, our research group has been using experimental models of pain and potential pharmacological and non-pharmacological treatments as object of study. The aim of this study was to assess whether the treatment with gabapentin is effective in reversing the muscle pain injury in rats with chronic myositis induced by the injection of Complete Freund\'s Adjuvant (CFA) in the gastrocnemius muscle. Also to analyze the influence of gabapentin on glial cells and pro-and anti-inflammatory cytokines in the central and peripheral nervous system of these animals. Our results demonstrate the effect of gabapentin on glial cells. This action are able to decrease expression of astrocytes and microglia, leadind to an increase in anti-inflammatory cytokines and inhibition of proinflammatory cytokines and an improvement of the nociceptive picture in our experimental mode. (AU) | |
| FAPESP's process: | 15/26038-0 - Evaluation of the gabapentin effect in model of chronic muscle pain in rats |
| Grantee: | Alyne Santana Rosa |
| Support Opportunities: | Scholarships in Brazil - Master |