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| Author(s): |
Cíntia Scucuglia Heluany
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-06-25 |
| Examining board members: |
Norma Yamanouye;
Alyne Simões Gonçalves;
Chao Yun Irene Yan
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| Advisor: | Norma Yamanouye |
| Abstract | |
Data in literature show that sympathetic outflow has a role only in stimulating synthesis and secretion of the saliva proteins in mammals. We show that after chronic treatment with reserpine, a sympatholytic drug, there were changes in the synthesis of different proteins in submandibular and parotid glands associated with various biological processes and subsequent administration of adrenoceptor agonists reversed these effects. Furthermore, in the parotid gland, stimulation of the sympathetic outflow is important to the process of exocytosis of secretory proteins. These results suggest that sympathetic outflow plays an important role for the functionality of the mouse salivary glands, namely, keeping these glands in a constant activated stage, regulating the synthesis of different proteins in these glands or promoting the exocytosis of saliva proteins. Furthermore, these results show that the sympathetic outflow acts differently in the mouse. (AU) | |
| FAPESP's process: | 10/13172-6 - Sympathetic nervous system on activation of mouse submandibular and parotid gland |
| Grantee: | Cintia Scucuglia Heluany |
| Support Opportunities: | Scholarships in Brazil - Master |