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| Author(s): |
Estevam José Baldon
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2014-02-05 |
| Examining board members: |
Osvaldo Augusto Brazil Esteves Sant\'Anna;
Miriam Galvonas Jasiulionis Leon;
Eliana Blini Marengo;
Eliana Faquim de Lima Mauro;
Nancy Starobinas
|
| Advisor: | Osvaldo Augusto Brazil Esteves Sant\'Anna |
| Abstract | |
Hsp are used for the development of autoimmunities and tumors treatments, however, the mechanism of action has not been fully enlightened. To verify the effect of Hsp65 in the aging, we analyzed aged ♀HIII leukocytes; using F1 hybrid mice we studied the genetic influence in Hsp65 susceptibility. Aged ♀HIII presented increase of T and B lymphocytes in the spleen and augmented APC in the blood. The survival of aged ♀F1H was reduced, similarly to aged ♀HIII previous results. The anti-Hsp65 IgG production increased in ♂F1 males, and the IgM was greater in all groups regardless of gender. In hybrid mice, only ♀F1 mice presented increased percentage of CD4 and CD8 activated T cells and of CD11c cells. The Hsp65 induces in vivo, activation of the immune system in aged ♀HIII and ♀F1 mice; the susceptibility to the protein can be given by specific gender effects and the genetic influence of the HIII strain. (AU) | |
| FAPESP's process: | 11/01220-9 - Genetic and environmental factors that act on the influence of Mycobacterium leprae rHsp65 in aging process and immune response of genetically selected mice. |
| Grantee: | Estevam José Baldon |
| Support Opportunities: | Scholarships in Brazil - Doctorate |