Anaphylaxis induced by Thalassophryne nattereri fish venom in mice.

Author(s)

Fernanda Miriane Bruni Soliani

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2012-03-27

Examining board members

Mônica Valdyrce dos Anjos Lopes Ferreira; Ana Paula Lepique; Carlos Roberto de Medeiros; Carla Máximo Prado; Nancy Starobinas

• Advisor: Mônica Valdyrce dos Anjos Lopes Ferreira

Abstract

Allergies are a significant and widespread public health problem. Anaphylaxis reactions are inducing by foods, medications and venoms and are IgE mediated. In mice, allergy can be caused also by IgG1. The results presented here describe for the first time anaphylaxis induced by Brazilian fish venom, accompanied by detailed characterization of soluble and cellular mediators involved in the process. Together our results demonstrated that the venom of T. natereri has allergenic proteins that can trigger allergic process, a phenomenon IgE-IgG1 dependent, IL-4 mediated and regulated by IFN-<font face=\"Symbol\">g. Furthermore, we observed a positive participation of the cytokines IL-12 and IFN-<font face=\"Symbol\">g in the exacerbation of the late phase reaction. (AU)