Full text
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| Author(s): |
Wanderson Romão
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Instituto de Química |
| Defense date: | 2010-11-11 |
| Examining board members: |
Marcos Nogueira Eberlin;
Adriano Otavio Maldaner;
Humberto Márcio Santos Milagre;
Maria Izabel Maretti Silveira Bueno;
Isabel Cristina Sales Fontes Jardim
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| Advisor: | Marcos Nogueira Eberlin |
| Abstract | |
The application of chemical analysis in the criminalistic field is a subject has always atract academic interesty. However in Brazil, this research field is still incipient. In this thesys, the chemical profiles of several drugs of abuse (amphetamines, piperazines, cocaine and LSD), documents and crude oil derivatives (gasoline, kerosene and diesel) were studied. For the analyzes of the drugs, easy ambient sonic-spray ionization mass spectrometry (EASI-MS) is shown to provide a relatively simple and selective screening tool to characterize and identify samples in their native form, as exemplified for ecstasy and LSD samples, sold in tablet and blotter forms, respectively. Mass spectrometry has also allowed the study of the ionic mobility of isomers derived of chlorophenilpiperazine (o-CPP, m-CPP e p-CPP). Only the m-CPP isomer is reported in the Brazilian lists of proscribed drugs (F and F2 Lists). It was also demonstrated that thin layer chromatography (TLC), although non expensive, reliable and versatile, may lead to false positives results. EASIMS combined with TLC provided a powerful screening tool for the analysis of street drugs with fast and indisputable results. An important technique available for the analysis of inorganic contaminants in drugs of abuse is the X-ray fluorescence (XRF) technique. XRF has several advantageous features such as multielemental capability, good detectivity, high precision, short analytical times, and is nondestructive. These characteristics make XRF applicable to a great variety of samples, offering an efficient technique for metal determinations in drugs of abuse. In this work, XRF followed by chemometric treatment has been applied to classify drugs of abuse. For analyzes of documents and banknotes (Brazilian real, dollar, and euro bills), two desorption/ionization techniques (DESI-MS and EASI-MS) were used as proof-of-principle techniques and ambient mass spectrometry was shown to function as a direct, nearly instantaneous, reproducible, and non-destructive method for their chemical analysis. An innovative and recently-introduced technique, Venture Easy Ambient Sonic-Spray Ionization Mass Spectrometry (V-EASI-MS), was also applied for rapid and reliable typification of gasoline samples and adulteration by addition of diesel and kerosene. Without any extraction or pre-treatment procedures, samples of gasoline, kerosene, diesel, and admixtures of gasoline/diesel and gasoline/kerosene were directly analyzed by VEASI(+)- MS (AU) | |
| FAPESP's process: | 09/07168-9 - New applications of mass spectrometry in Forensic Chemistry |
| Grantee: | Wanderson Romão |
| Support Opportunities: | Scholarships in Brazil - Doctorate |