Clinical aspects and genotype of the FSH receptor in hCG-induced ovarian hyperstimulation syndrome

Author(s)

Catarina Brasil D'Avila Rocha

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD)
• Defense date: 2006-07-07

Examining board members

Berenice Bilharinho de Mendonca; Mauricio Simões Abrão; Ivo Jorge Prado Arnhold; Sylvia Asaka Yamashita Hayashita; Ieda Therezinha do Nascimento Verreschi

• Advisor: Berenice Bilharinho de Mendonca

Abstract

Ovarian hyperstimulation syndrome (OHSS) can occur spontaneously during early pregnancy or as an iatrogenic complication in assisted reproductive medicine. The aim of this study was to identify clinical and hormonal risk factors for iatrogenic OHHS and to evaluate the role of allelic variants of the FSHR in the etiology of this syndrome. We studied 29 patients with moderate and severe iatrogenic OHHS. Age < 33.5 y, basal FSH < 5.2 U/L and estradiol response during ovarian stimulation > 1757 pg/mL were independent risk factors for iatrogenic OHSS and these three factors in association were able to predict the syndrome with accuracy of 78%. We did not find mutations in any patient studied. However, there was a predominance of the Asn680 allele of Ser680Asn polymorphism in patients with the most severe forms of the syndrome (AU)