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| Author(s): |
Lílian Rêgo de Carvalho
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-03-18 |
| Examining board members: |
Olga Célia Martinez Ibañez;
Jose Alexandre Marzagao Barbuto;
Anna Carla Renata Krepel Goldberg
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| Advisor: | Olga Célia Martinez Ibañez |
| Abstract | |
Inflammatory components are an essential part of the tumor microenvironment being crucial in some types of cancer. Our objective was to study the influence of genetic factors relevant to inflammatory response regulation on cancer development by the comparative analysis of carcinogen-induced liver and lung tumors in AIRmax and AIRmin mouse strains, genetically selected for maximum and minimum inflammatory responsiveness. The carcinomas were induced by the injection of Urethane or DEN. 32 weeks after treatment, most AIRmax had liver tumors whereas AIRmin mice were resistant. The inverse occured in lungs: all AIRmin were affected and the incidence in AIRmax was 27.3%. The acute phase proteins IL-6, TNF<font face=\"Symbol\">a and IL-1<font face=\"Symbol\">b seem to be important in this process, with increased production in target organs hours after drug injection. These results provide a demonstration that a group of genes controls the inflammatory response and susceptibility or resistance to different types of cancers and also highlight the specific role of local cells in the control of tumor immunity. (AU) | |
| FAPESP's process: | 11/01699-2 - Inflammation and hepatic and lung cancer in mouse lines selected for high or low acute inflammatory response |
| Grantee: | Lilian Rego de Carvalho |
| Support Opportunities: | Scholarships in Brazil - Master |