Cardiovascular evaluation and determination of atherosclerotic factors in obese dogs

Author(s)

Beatriz Kiihl Roque

• Document type: Master's Dissertation
• Press: Pirassununga.
• Institution: Universidade de São Paulo (USP). Faculdade de Zootecnica e Engenharia de Alimentos (FZE/BT)
• Defense date: 2017-09-13

Examining board members

Deise Carla Almeida Leite Dellova; Roberta Ariboni Brandi; Maria Lucia Gomes Lourenço; Daniele dos Santos Martins

• Advisor: Deise Carla Almeida Leite Dellova

Abstract

Cardiovascular alterations and hyperlipidemia are common in obese dogs. In humans, apolipoproteins (Apos) are part of lipid profile and are used to determine the atherosclerosis, vascular and cardiac diseases risks. Therefore, the objective of this study was to relate the cardiovascular changes with atherosclerotic factors, also verifying the weight loss influence on such factors and cardiac and pressure parameters. Twenty neutered dogs female, 9 with ECC 4-5 (control group) and 11 with ECC 8-9 (obesity group) participated of this study. In relation to control group, the obesity group presented the increase of: fat mass (in kg and %), leukocyte counts, systolic blood pressure (BP), triglyceride and VLDL concentrations, as well as the higher number of females with cystitis and ventricular hypertrophy signs. These parameters returned the control situation after weight loss, except the cases of cystitis. Comparing the mean values, the control and obesity groups did not differ in the electrocardiographic and echocardiographic evaluations and in Apo A-I and B concentrations. The results indicate that the reduction of body fat has benefits, due to cholesterol (total, LDL and VLDL) and triglycerides decrease and improvement of cardiovascular evaluation. In addition, Apo A-I and Apo B determination may assist in lipid profile assessing, but were not related to cardiovascular changes observed in obese female dogs. (AU)

• FAPESP's process: 14/27242-7 - Cardiovascular evaluation and determination of atherosclerotic factors in obese dogs
• Grantee: Beatriz Kiihl Roque
• Support Opportunities: Scholarships in Brazil - Master