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| Author(s): |
Tatiane Aparecida Canhamero Gasparelo
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2015-02-26 |
| Examining board members: |
Marcelo de Franco;
Gustavo Pompermaier Garlet;
Eliana Faquim de Lima Mauro;
Sonia Jancar Negro;
Geraldo Aleixo da Silva Passos Junior
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| Advisor: | Marcelo de Franco |
| Abstract | |
Homozygous AIRmax and AIRmin sublines for Slc11a1 R and S alleles differ in the ability to repair to the ear hole. AIRmaxSS mice exhibited regeneration 30 days after ear punch while AIRminSS animals did not show regeneration. The regeneration observed in AIRmaxSS mice was due to lower inflammation at the beginning of repair process resulting in less deposition of collagen and expression of a-SMA protein in the ears of these animals. Down regulated genes related with muscle contraction was observed in AIRmaxSS mice. In addition, AIRminSS mice presented gene cluster on chromosome 11 with expression profile that predispose them to wound healing with scar. These results suggest that the importance of regulating inflammation in the initial events and the activation and repression of some genes related to the wound healing phenotype can drives tissue regeneration or wound healing after ear punch. (AU) | |
| FAPESP's process: | 09/14452-5 - Influence of acute inflammatory response loci on determination of tissue repair or regeneration in genetically selected mice for maximum or minimum acute inflammatory response. |
| Grantee: | Tatiane Aparecida Canhamero Gasparelo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |