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| Author(s): |
Tiago Bueno de Moraes
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Carlos. |
| Institution: | Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC/BT) |
| Defense date: | 2016-05-19 |
| Examining board members: |
Luiz Alberto Colnago;
Antonio Gilberto Ferreira;
Sonia Maria Cabral de Menezes;
Alberto Tannus;
Cláudio Francisco Tormena
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| Advisor: | Luiz Alberto Colnago |
| Abstract | |
The application of a pulse sequence with repetition time much smaller than the relaxation times, Tp << T2; T1, causes the magnetization to reach a steady state, described by H. Y. Carr as a Steady State Free Precession (SSFP). In this condition, the signal is composed of the complex overlapping of the FID and eco components. SSFP type sequences are used in fast acquisition of NMR signals, resulting in a good signal to noise ratio (s/r) in a short time interval, however, they introduce phase and amplitude anomalies due to the complex interaction between the components of the steady state. In this work, we develop SSFP type pulse sequences for NMR in high and low resolution, with alternation and increment of phase. In high resolution, we develop SSFPdx and SSFPdxdt sequences, with linear and quadratic phase increment respectively. Results show that the low sensitivity nuclei spectra can be obtained with the same s/r ratio in smaller experimental time, about an order of magnitude, and the developed sequences can remove the spectral anomalies. In low resolution, the results show that the introduction of a phase alternation in the Continuous Wave Free Precession (CWFP) allows the elimination of the dependence of the sequence with the offset frequency and the time between pulses. Besides, we show that the CP-CWFPx-x sequence with a small refocalization angle (5° to 10°) allows the fast estimative of the longitudinal relaxation time in a single experiment. The results of the studies conducted during an international research internship are also presented. Steady state pulse sequences – DECPMG and Split 180° – were studied and implemented in compact magnetic systems: mini-Halbach and MOUSE-NMR. Finally, the results of the application of the Krylov Basis Diagonalization Method (KBDM) and the Inverse Laplace Transform for the analysis of SSFP signals are presented. The results show that KBDM is a useful tool in data processing for low and high resolution, both for obtaining spectra and determining the relaxation times distribution. (AU) | |
| FAPESP's process: | 11/11160-3 - Development of steady state free precession (SSFP) sequences with phase alternation for rapid acquisition of high resolution NMR spectra |
| Grantee: | Tiago Bueno de Moraes |
| Support Opportunities: | Scholarships in Brazil - Doctorate |