Effects of creatine supplementation on renal function of practitioners of strength training: a randomized, double-blind, placebo controlled study

Author(s)

Rebeca Lugaresi Anadon Refusta dos Santos Netto

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Escola de Educação Física e Esportes (EEFE/BT)
• Defense date: 2013-08-08

Examining board members

Bruno Gualano; Elisa Mieko Suemitsu Higa; Hamilton Augusto Roschel da Silva

• Advisor: Bruno Gualano

Abstract

The effects of creatine supplementation on renal function are discussed extensively in the literature. Few studies on the topic involving humans have been severely criticized because of the absence of randomization, non-uniform doses of creatine, low statistical power and, above all, the absence of a gold standard markers of renal function. Furthermore, although we have recently shown that creatine supplementation does not impair renal function in subjects undergoing aerobic training, the nature of this type of activity, as well as the usual protein intake in this sample does not allow generalization of our findings to the population who consume creatine: practitioners of strength training with a high protein intake. Thus, we conducted a randomized, double-blind, placebo-controlled study, in order to investigate the effects of creatine supplementation and its possible interaction with high protein intake on renal function in practicioners of strength training. The subjects were randomly assigned to 2 groups: a) creatine supplementation (20g/day during five days and 5g/day until the end of the study) and b) placebo (dextrose). At baseline and after 12 and 24 weeks, food intake, 51Cr-EDTA clearance, serum creatinine, sodium and potassium serum and urinary microalbuminuria was assessed. No significant differences were observed throughout the trial. Demonstrating that creatine supplementation on practitioners of strength training with high protein intake does not harm renal function (AU)

• FAPESP's process: 10/13345-8 - Effects of creatine supplementation on renal function of practitioners of strenght training: a randomized, double-blind, placebo-controlled
• Grantee: Rebeca Lugaresi Anadon Refusta dos Santos Netto
• Support Opportunities: Scholarships in Brazil - Master