Investigation of neuroplasticity associated with the therapeutic effects of electrical cortical stimulation in animal models of complex painful syndromes.

Author(s)

Adriano Cardozo Franciosi

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2017-04-12

Examining board members

Camila Squarzoni Dale; Silvana Chiavegatto; Ricardo Galhardoni; Roberto de Pasquale; Manoel Jacobsen Teixeira

• Advisor: Camila Squarzoni Dale

Abstract

Chronic widespread pain is the main symptom of fibromyalgia. Without specific treatment, an emerging alternative for the treatment of refractory patients is the motor cortex stimulation (MCS) through non-invasive techniques. The analgesic mechanisms of MCS are poorly understood, being linked to neuroplasticity in the pain matrix. A fibromyalgia model was induced in rats by administration of reserpine (2 mg/kg for 3 consecutive days) and mechanical sensitivity was assessed. The ECM (1V, 210μs and 60Hz, 15 minutes per session) restored the mechanical sensitivity in the fibromyalgia model, with one or 5 sessions. In the posterior horn of the spinal cord, ECM restored the BDNF levels decreased in the fibromyalgia model, and decreased the phosphorylation of TrkB. In the PAG, ECM increased GDNF but decreased GFAP and phosphorylation of AKT and ERK-1/2. In ACC, ECM decreased AKT phosphorylation, increased BDNF, and maintained normal GFAP levels in the model. Thus, the antinociceptive effect of ECM is associated with several neuroplastic alterations. (AU)

• FAPESP's process: 12/03865-0 - Investigation of neuroplasticity associated with the therapeutic effects of electrical cortical stimulation in animal models of complex painful syndromes
• Grantee: Adriano Cardozo Franciosi
• Support Opportunities: Scholarships in Brazil - Doctorate