Full text
| |
| Author(s): |
Jussara Gonçalves Fernandes
Total Authors: 1
|
| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2012-09-13 |
| Examining board members: |
Marcelo de Franco;
Sonia Jancar Negro;
Silvio Luis de Oliveira
|
| Advisor: | Marcelo de Franco |
| Abstract | |
AIRmax and AIRmin mouse lines differ in terms of acute inflammatory response after Biogel injection. The distinct AIR in these lines is well established, however, differences in late or chronic inflammatory response to Biogel were not described yet. Thus, we decided to check if the genetic selection that modified the acute inflammatory response in these lines, also affected the development of a chronic inflammatory response. We found that AIRmax mice had higher cellular influx in the inflammatory exudate than AIRmin mice in both analyzed periods (48h and 30d) and that after 48 hours of Biogel injection, AIRmax mice showed higher cytokine levels in inflammatory exudates. This line also showed higher number of up regulated genes in AIRmax than in AIRmin mice involved with inflammatory response, immune response and signal transduction. Some acute inflammatory response genes also showed differences on day 30. Our results indicate that the genetic selection for acute inflammatory response may also have affected the chronic inflammatory response to Biogel. (AU) | |
| FAPESP's process: | 09/12477-0 - Comparative analysis of acute and chronic inflammatory processes of the subcutaneous tissue and exudate in mice genetically selected for maximal or minimal inflammation. |
| Grantee: | Jussara Gonçalves Fernandes |
| Support Opportunities: | Scholarships in Brazil - Master |