Structural and biophysical studies of hexameric purin nucleoside phosphorylase of Bacillus subtillis

Author(s)

Nádia Helena Martins

• Document type: Doctoral Thesis
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia
• Defense date: 2011-08-26

Examining board members

Mário Tyago Murakami; Ana Carolina de Mattos Zeri; Andrea Balan; Fernanda Canduri; Ronaldo Alves Pinto Nagem

• Advisor: Mário Tyago Murakami

Abstract

The hexamcric purine nucleoside phosphorylase from Bacillus subtilis (BsPNP233) is a nucleoside phosphorylase typc-1 involved in purine salvage pathway by the nucleoside phosphorolysis resulting in purine base and ribose-1-phosphatc. The interest about this enzyme involves gene therapy application in solid cancers treatment and nucleoside analogs biosynthesis...Note: The complete abstract is available with the full electronic document (AU)