Morphogeometric evaluation of the left ventricle and left atrioventricular ring in healthy dogs: a computerized study

Author(s)

Catarina Borges Cardoso

• Document type: Master's Dissertation
• Press: Botucatu. 2021-07-15.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu
• Defense date: 2021-05-03
• Advisor: Claudia Valéria Seullner Brandão

Abstract

Anatomy is an extremely necessary field of knowledge for the development of any therapeutics, especially surgical ones. It is important to study cardiac morphogeometric changes as a result of pathological remodeling, a phenomenon present in many heart diseases, which contributes to the evolution to heart failure and death. These are rare in dogs, considering anatomical parts. In addition, ventricular geometry can act as an indicator of cardiac function. Thus, we aim to obtain measurements of the left atrioventricular ring and left ventricle, to analyze the proportionality between the segments of the normal left cardiac chamber and to establish parameters for morphogeometric analysis. For this purpose, 50 hearts from small (≤10 kg, G1) and medium to large (≥10 kg, G2) dogs, were laminated in apical, basal and equatorial segments, which were subjected to computerized analysis to identify values such as segmental perimeters and mitral valve annulus, wall thickness and distance from the atrioventricular groove to the apex. The largest internal perimeter was the equatorial segment (p <0.001, G1). The basal segment showed a higher mean for ventral wall thickness, suggesting a greater contractile reserve in this location. Regarding the proportionality relations, there was no statistical difference between the perimeter intersegmental indexes for the two groups; this allows us to suggest that although the animal´s weight varies, the proportions between the left ventricular segments remains. Therefore, this study provides useful information as a comparison standard for geometric assessments of any cardiac disorders, as well as a basis for the development of therapeutic procedures in the face of adverse cardiac remodeling. (AU)

• FAPESP's process: 19/02131-1 - Morphometric evaluation of the ventricle and mitral valve ring of healthy dogs: a computerized study
• Grantee: Catarina Borges Cardoso
• Support Opportunities: Scholarships in Brazil - Master