Development of latex-alginate and latex-collagen polymer blends for application in tissue engineering

Author(s)

Natan Roberto de Barros

• Document type: Doctoral Thesis
• Press: Araraquara. 2020-07-09.
• Institution: Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara
• Defense date: 2020-05-20
• Advisor: Rondinelli Donizetti Herculano

Abstract

Natural latex from the rubber tree Hevea brasiliensis can stimulate tissue regeneration, this occurs by the formation of blood capillaries that increase vascularization at the site of its application. However, the application of natural latex faces challenges such as increased exudate when applied to diabetic wounds, the need for surgical removal when used as an implant, among others. Therefore, it is necessary to develop matrices that have the characteristic of natural latex to stimulate tissue regeneration, combined with other properties, such as fluid absorption in applications in the treatment of exudative lesions, increased material degradability in treatments where the implant it is necessary, and the supply of nutrients that assist in tissue regeneration. The present work presents the results of the development and characterization of membranes composed of natural latex, alginate, and collagen. Through standard techniques for characterizing biomaterials, it was observed that, due to their mechanical, chemical, and biological properties, membranes composed of bNRL, alginate, and collagen show great promise for the treatment of dermal wounds such as diabetic ulcers. The biocompatibility of the membranes and the ability to create a favorable environment around the wound bed are key characteristics that contribute to its value in facilitating and accelerating tissue regeneration. (AU)

• FAPESP's process: 17/02518-8 - Development of polymer blends of latex-alginate and latex-collagen for tissue engineering application
• Grantee: Natan Roberto de Barros
• Support Opportunities: Scholarships in Brazil - Doctorate