Evaluation of moderate intensity physical exercise (swimming) in oxidative stress, sex hormones and pancreatic proliferation in pregnant diabetic rats

Author(s)

Nathália Cristine Dias Macedo

• Document type: Master's Dissertation
• Press: Botucatu. 2016-04-07.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu
• Defense date: 2016-02-18
• Advisor: Débora Cristina Damasceno

Abstract

Objective: To evaluate glycemic, proliferation and oxidative stress markers in moderate diabetic rats submitted to moderate intensity swimming during pregnancy. Methods: Wistar rats were used. At birth, female rats were assigned either to control or diabetic group (100 mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated and confirmed the pregnancy, were divided into four groups: nondiabetic non exercised, nondiabetic exercised, diabetic non exercised and diabetic exercised. The exercised groups carried loads equivalent to 4% of body weight. The rats were used for analysis of reproductive performance, oxidative stress biochemical markers and morphometric and immunohistochemical analysis of endocrine pancreas. Results: Swimming altered carbohydrate metabolism positively and improved the antioxidant defense in nondiabetic rats, which contributes to good maternal reproductive performance. In diabetic animals, swimming did not affect pancreatic function, increased muscle damage, decreased antioxidant defense, but did not cause damage to fetal development. Conclusions: Therefore, swimming moderate exercise was beneficial to nondiabetic rats. This same exercise conditions established for healthy animals, however, should not be applied to diabetic rats because it have different responses presented in our study after the implementation of the exercise. (AU)

• FAPESP's process: 13/23478-3 - Evaluation of exercise (swimming) with moderate intensity on oxidative stress, sex hormonal status and pancreatic proliferation of pregnant diabetic rats
• Grantee: Nathália Cristine Dias de Macedo
• Support Opportunities: Scholarships in Brazil - Master