Hearing evaluation of children with congenital hypothyroidism
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Hearing evaluation in children congenital hypothyroidism
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| Author(s): |
Amanda Ferreira Hernandez Rogério
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas |
| Defense date: | 2015-04-28 |
| Examining board members: |
Maria Francisca Colella Santos;
Ana Claudia Vieira Cardoso;
Christiane Marques do Couto
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| Advisor: | Maria Francisca Colella Santos; Maria Cecilia Marconi Pinheiro Lima |
| Abstract | |
The Thyroid hormones are essential for the growth and development of various organs and tissues of vertebrates and, although the pathophysiological mechanisms of hearing loss in hypothyroidism is not fully established, studies indicate that auditory alterations may occur in 20% of children with Congenital hypothyroidism (CH) and the abnormalities of hearing remain even when they are treated.Objective: To analyze the hearing of infants with Congenital Hypothyroidism through electrophysiological evaluation and behavioral, considering the age, sex, right and left ears and hormone levels of free T4 and TSH. Methodology: The sample was composed of 22 children of group Congenital Hypothyroidism (GHC) and 16 children in the control group (CG) without thyroid disease, both groups with age from 0 to 24 months. The audiological evaluation was composed of electrophysiological tests and behavioral, such as the Brainstem Evoked Response Audiometry (BERA), Transient Evoked Otoacoustic Emissions (TEOAE), TEOAE suppression, tympanometry, Minimum Response Levels (MRL) and instrumental evaluation. Results: The GHC showed lower TEOAE amplitude when compared to the CG. Negative correlation was observed for the hormone levels of TSH and free T4 with the ABR results for latency of wave V 60 dB and interpeak interval latencies I-III to 80 dB. GHC presented performance statistically inferior to the behavioral tests. Conclusion: based on the analysis of the results obtained in the audiological evaluation it can be concluded that children with congenital hypothyroidism in our study showed decreased amplitude of Transient Evoked Otoacoustic Emissions, which can reveal changes with cochlear functioning impaired external ciliated cells. Furthermore, presented auditory development suffers (AU) | |
| FAPESP's process: | 12/25012-9 - Hearing evaluation of children with congenital hypothyroidism |
| Grantee: | Amanda Ferreira Hernandez Rogério |
| Support Opportunities: | Scholarships in Brazil - Master |