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| Author(s): |
Marcele Fonseca Passos
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Química |
| Defense date: | 2016-07-07 |
| Examining board members: |
Rubens Maciel Filho;
Rodrigo Alvarenga Rezende;
Angela Cristina Malheiros Luzo;
Aulus Roberto Romão Bineli;
Viktor Oswaldo Cárdenas Concha
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| Advisor: | Carmen Gilda Barroso Tavares Dias; Rubens Maciel Filho |
| Abstract | |
The incessant search to meet physiological and anatomical conditions of organs and / or tissue damage has been integrating various scientific areas. Biologists, physicists, chemists, pharmacists, engineers and doctors contribute gradually in the synthesis and characterization of biomaterials for use in Tissue Engineering. Polymers such as poly (L - lactic acid) (PLLA) and poly (2-hydroxyethyl methacrylate) (PHEMA) are some of the interesting materials for this application. The PLLA offers the advantage of being hydrophobic polyester, which in vivo degrades into non-toxic components. The PHEMA offers the possibility of easy modification of the structure by simply replacing of the acrylate component becoming chemically adjustable in terms of hydrophilicity, pH and temperature. However, these biomaterials have limitations as cell adhesion and mechanical properties, respectively. And little is known about the synergistic effects of union between them. Polymerization's strategies such as addition of hydrophilic segments in the structure of PLLA or the presence of hydrophobic comonomer content in the chain of PHEMA in turn, can improve the mentioned deficiencies. Bearing all this is mind, this thesis focused on obtaining biomaterials with physicochemical characteristics and mechanical suitable for medical application, from the simultaneous synthesis of PHEMA and PLLA. Different synthesis routes have been adopted, such as bulk polymerization, solution polymerization and chemical vapor deposition at atmospheric pressure and vacuum. Semi-interpenetrating networks (IPNs or semi-IPNs) of PHEMA-PLLA were successfully obtained using conventional polymerization techniques (mass and solution). Biological assays showed good cell adhesion and proliferation and biomaterial's potential use for artificual articular cartilage and cancellous bone. Computer simulations by Aspen Pus® and Computational Fluid Dynamics (CFD) software were performed to evaluate the synthesis of semi-interpenetrating network from the initiated chemical vapor deposition technique (iCVD). The fluid dynamic data associated with the estimation of physical properties of the reagents were determined, and appropriate values of temperature distribution in the reaction zone (150 °C) and the speed of the fluid (0.142 m / s) in iCVD system at atmospheric pressure were obtained. Maximum speed profiles to vacuum system were found to 2 m / s. Results of synthesis using iCVD reactors, on the other hand, show the kinetic complexity of the system and the significant influence of thermodynamic parameters to obtain materials (AU) | |
| FAPESP's process: | 11/18525-7 - IPNs networks of pHEMA-PLA for use in Tissue Engineering |
| Grantee: | Marcele Fonseca Passos |
| Support Opportunities: | Scholarships in Brazil - Doctorate |