Effects of peripheral demyelinating polyneuropathies in motor control tasks studied with a multiscale neuromuscular model.

Author(s)

Marina Cardoso de Oliveira

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Escola Politécnica (EP/BC)
• Defense date: 2021-11-19

Examining board members

Andre Fabio Kohn; Leonardo Abdala Elias; Renato Naville Watanabe

• Advisor: Andre Fabio Kohn

Abstract

This work aims to study the problem of locating two differential electrodes on the thoracic surface, whose main function would be reading the electric potential generated by the heart beat. The problem is motivated by the need to efficiently include this type of reading in an electrical impedance tomography device. The work then proposes a modular method to solve the problem, clarifies the different steps, and gives a practical example. The methodology can be broken down to four main modules: Modeling of the physiological system, elaboration of a discrete model (ex: finite elements), solution of the inverse problem and the choice of electrode position. The modules are independent in many aspects, which means the present work could easily be continued in the form of an in-depth study of any one of them. At each step different solution methods are discussed, as well as limitations and possible improvements. A simplified case study covering all the steps presented is used to exemplify and validate the work. A simple prism with an eliptical base is used to represent the torso, based on the geometry found on [11]. The heart is represented by a sphere located inside this solid. The electric potential is calculated analytically inside this region using an ideal dipole as source, and numerically for the rest of the torso, as seen on [13]. (AU)

• FAPESP's process: 19/09885-1 - Mathematical modeling of myelinated axons in a large-scale model of the neuromuscular system for the study of demyelinating diseases
• Grantee: Marina Cardoso de Oliveira
• Support Opportunities: Scholarships in Brazil - Master