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| Author(s): |
Leonardo Francisco Gonçalves Dias
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Bauru. 2022-12-19. |
| Institution: | Universidade Estadual Paulista (Unesp). Faculdade de Ciências. Bauru |
| Defense date: | 2022-11-18 |
| Advisor: | Paulo Noronha Lisboa Filho |
| Abstract | |
Bisphosphonates are a class of organic molecules used for bone growth, however, the prolonged use of these molecules is related to mandibular osteonecrosis. To maintain the ability to promote bone growth, the immobilization of these molecules on the surface of implants is an alternative to increasing the biocompatibility of implants without presenting the side effects of prolonged exposu re. This thesis aims to collaborate with data and discussions of bisphosphonates immobilized on TiO2 surfaces of hydroxyapatite (HA), based mainly on measurements of X-ray photoelectron spectroscopy, zeta potential, and atomic force microscopy. First, layers of octadecylphosphonic acid on TiO2 obtained by sputtering were investigated, then bisphosphonates on different surfaces, such as TiO2 by sol-gel and hydroxyapatite. Data obtained from computer simulation were used and discussed together with the experimental data. The results indicate that bisphosphonates adsorb on the surface exposing the phosphonate groups, and promoting a hydrophilic surface. Furthermore, changes in pH alter the surface charge due to the presence of P-OH and -N+ species. On titanium dioxide surfaces, adsorption can be enhanced by the hydroxylation process, as shown in the adsorption curves of bisphosphonates. No cytotoxic effect was observed on prepared samples. The applied strategy is a suitable strategy for the investigation of bioactive molecules and can be used as a basis for other compounds. (AU) | |
| FAPESP's process: | 18/07520-3 - Immobilization of bisphosphonates on nanostructured surface films of TiO2 and hydroxyapatite |
| Grantee: | Leonardo Francisco Gonçalves Dias |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |