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| Author(s): |
Carine Marmentini
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia |
| Defense date: | 2023-05-26 |
| Examining board members: |
Antonio Carlos Boschero;
Adriana Souza Torsoni;
Carmen Veríssima Ferreira;
Maria Lúcia Bonfleur;
Sandra Lucinei Balbo
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| Advisor: | Mirian Ayumi Kurauti; Antonio Carlos Boschero |
| Abstract | |
Human islet amyloid polypeptide (hIAPP) is a hormone co-secreted with insulin by pancreatic beta cells and is the major component of islet amyloid. Islet amyloid is mainly found in the islets of type 2 diabetic patients and may be involved in pancreatic beta cells dysfunction and death in this disease. The insulin-degrading enzyme (IDE) is one of the main enzymes responsible for hIAPP degradation and it was shown that IDE expression can be modulated by peroxisome proliferator-activated receptor... The abstract is available with the full electronic document (AU) | |
| FAPESP's process: | 18/24368-0 - Action of PPAR gamma (Peroxisome Proliferator Activated Receptor gamma) and AMPK (AMP-activated protein kinase) on the expression of IDE (Insulin Degrading Enzyme) in pancreatic beta cells |
| Grantee: | Carine Marmentini |
| Support Opportunities: | Scholarships in Brazil - Doctorate |