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| Author(s): |
Ana Catarine da Veiga Oliveira
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Ribeirão Preto. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) |
| Defense date: | 2024-08-08 |
| Examining board members: |
Hugo Celso Dutra de Souza;
Maria Claudia Costa Irigoyen;
Luiz Carlos Marques Vanderlei
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| Advisor: | Hugo Celso Dutra de Souza |
| Abstract | |
COVID-19 causes systemic inflammation, mainly in the respiratory tract, with varying degrees of severity, as well as secondary and late attacks. In late attacks, autonomic dysfunction is suspected to occur, which may compromise cardiovascular homeostasis and increase susceptibility to the development and/or worsening of cardiovascular disease. Therefore, the aim of this study was to investigate the late effects on cardiovascular autonomic parameters in asymptomatic and symptomatic individuals affected by COVID-19. Methods: 85 healthy men aged 35 to 55 years were divided into an asymptomatic group (N=43) and a symptomatic group (42), the latter consisting of patients who had recovered for more than 6 months. Both groups were subjected to the following experimental procedures: recording of anthropometric, hemodynamic and echocardiographic parameters; impulse oscillometry test; assessment of cardiorespiratory fitness by cardiopulmonary testing; analysis of heart rate variability (HRV) and blood pressure (VPA) using different approaches; and assessment of baroreflex sensitivity (BRS). Results: Both groups presented similar anthropometric, hemodynamic, cardiac morphofunctional and airway resistance values. Regarding the autonomic assessment, our results showed no differences in HRV between the groups in the supine position, except for the approximate entropy (ApEn), which was higher in the symptomatic group. On the other hand, during the tilt test, the linear analysis showed that the symptomatic group had lower values of high-frequency oscillations (HF; 0.15 - 0.4 Hz) and reduced low-frequency oscillations (LF; 0.04 - 0.15 Hz), both in standard units. It also showed that the symptomatic group showed no differences between the supine and tilt test regarding LF oscillations in absolute units. In addition, nonlinear analysis showed an increase in ApEn and sample entropy during the tilt test, and a decrease in α1 when trend-cleared fluctuation analysis was applied. Again, there were no differences between the groups concerning VPA and SBR. Conclusion: Analysis of heart rate variability suggests a reduction in sympathetic modulation and an increase in randomness and unpredictability in symptomatic men affected by COVID-19, particularly during the tilt test. (AU) | |
| FAPESP's process: | 22/02006-5 - SARS-CoV-2 and late effects on cardiovascular autonomic parameters |
| Grantee: | Ana Catarine da Veiga Oliveira |
| Support Opportunities: | Scholarships in Brazil - Master |