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Evaluation of hypervariable regions from genes predisposing to obesity

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Author(s):
Hamilton Massayuki Hinuy
Total Authors: 1
Document type: Master's Dissertation
Press: São Paulo. , ilustrações.
Institution: Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ)
Defense date:
Examining board members:
Rosario Dominguez Crespo Hirata; Ligia Ferreira Gomes; Sandra Mara Ferreira Villares
Advisor: Rosario Dominguez Crespo Hirata
Field of knowledge: Health Sciences - Pharmacy
Indexed in: Banco de Dados Bibliográficos da USP-DEDALUS; Biblioteca Digital de Teses e Dissertações - USP
Location: Universidade de São Paulo. Biblioteca do Conjunto das Químicas
Abstract

The genetic variants LEP G-2548A, LEP 3\'HVR, D1S200 (LEPR), D18S858 (MC4R) D2S1788 (POMC) were studied in groups of 100 obese (GE) and 110 non-obese (GC) white individuals. Genotyping were carried out by PCR and RFLP techniques. Alleles frequencies from LEP -2548G and Class I alleles from LEP 3\'HVR were higher in GE group, when compared to GC group (P<0,05). The LEP G/I haplotype was more frequent in GE group (P=0,018) and in individuals with central obesity (P=0,047). Alleles 41/42 from D18S858 and allele 17 from D1S200 were more frequent (P<0,05) in GE group. Individuals carrying LEP 3\'HVR-Class I, alleles 41/42 from D18S858 and allele 17 from have shown elevated body mass index (BMI) and waist circumference values (P<0,05). In conclusion, the LEP G-2548A, LEP 3\' HVR, D1S200, and D18S858 genetic variants were found to be associated to obesity and variations in BMI and waist circumference in Brazilian white individuals. (AU)

FAPESP's process: 00/11700-3 - Evaluation of hypervariable regions from genes predisposing to obesity
Grantee:Hamilton Massayuki Hinuy
Support Opportunities: Scholarships in Brazil - Master