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| Author(s): |
Hamilton Massayuki Hinuy
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. , ilustrações. |
| Institution: | Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) |
| Defense date: | 2004-04-02 |
| Examining board members: |
Rosario Dominguez Crespo Hirata;
Ligia Ferreira Gomes;
Sandra Mara Ferreira Villares
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| Advisor: | Rosario Dominguez Crespo Hirata |
| Field of knowledge: | Health Sciences - Pharmacy |
| Indexed in: | Banco de Dados Bibliográficos da USP-DEDALUS; Biblioteca Digital de Teses e Dissertações - USP |
| Location: | Universidade de São Paulo. Biblioteca do Conjunto das Químicas |
| Abstract | |
The genetic variants LEP G-2548A, LEP 3\'HVR, D1S200 (LEPR), D18S858 (MC4R) D2S1788 (POMC) were studied in groups of 100 obese (GE) and 110 non-obese (GC) white individuals. Genotyping were carried out by PCR and RFLP techniques. Alleles frequencies from LEP -2548G and Class I alleles from LEP 3\'HVR were higher in GE group, when compared to GC group (P<0,05). The LEP G/I haplotype was more frequent in GE group (P=0,018) and in individuals with central obesity (P=0,047). Alleles 41/42 from D18S858 and allele 17 from D1S200 were more frequent (P<0,05) in GE group. Individuals carrying LEP 3\'HVR-Class I, alleles 41/42 from D18S858 and allele 17 from have shown elevated body mass index (BMI) and waist circumference values (P<0,05). In conclusion, the LEP G-2548A, LEP 3\' HVR, D1S200, and D18S858 genetic variants were found to be associated to obesity and variations in BMI and waist circumference in Brazilian white individuals. (AU) | |
| FAPESP's process: | 00/11700-3 - Evaluation of hypervariable regions from genes predisposing to obesity |
| Grantee: | Hamilton Massayuki Hinuy |
| Support Opportunities: | Scholarships in Brazil - Master |