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Effect of simvastatin, alpha-tocopherol and L-arginin on the endogenous nitric oxide synthase inhibitors, nitric oxide metabolites and thiols in hypercholesterolemic patients

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Author(s):
Edimar Cristiano Pereira
Total Authors: 1
Document type: Master's Dissertation
Press: São Paulo. , gráficos, ilustrações, tabelas.
Institution: Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ)
Defense date:
Examining board members:
Dulcineia Saes Parra Abdalla; Marcelo Chiara Bertolami; Ligia Ferreira Gomes
Advisor: Dulcineia Saes Parra Abdalla
Field of knowledge: Biological Sciences - Biochemistry
Indexed in: Banco de Dados Bibliográficos da USP-DEDALUS
Location: Universidade de São Paulo. Biblioteca do Conjunto das Químicas; FCF T/616.0756; P436e
Abstract

The aim of this study was to evaluate the effect of sinvastatin, isolated and associated to α-tocopherol and to L-arginine, on the endogenous inhibitors of nitric oxide synthase, on nitric oxide metabolytes and thiols, in hypercholesterolemic patients. A group of 16 hypercholesterolemic patients were analysed, acconting to the protocol: a washout period (without medication) of 1 month, sinvastatin (20 mg/day) for 2 months; sinvastatin (20 mg/day) + α-tocopherol (400U/day) for 2 months; sinvastatin (20 mg/day) for 1 months (washout period), sinvastatin (20 mg/day) + L-arginine (7g/day) for 2 months. Sinvastatin significantly reduced the concentrations of total cholesterol and LDL-cholesterol, as well as the LDL-cholesterol/HDLcholesterol ratio. The treatment with sinvastatina, alone and associate to α-tocoferol, resulted in a reduction of RSNO concentration. The L-arginine associated with sinvastatin, increase the level of total cholesterol as compared with simvastatin alone. The plasma concentrations of a-tocopherol and Larginine did not increase following supplementation due to the large dispersion of the data obtained, even though the median plasma concentrations of L-arginine and a-tocopherol were elevated after supplementation. Treatment with simvastatin, alone or associated to L-arginine and a-tocopherol did not alter the concentrations of the endogenous inhibitors of nitric oxide synthase (ADMA and SDMA), or that of nitric oxide metabolytes, total nitrotyrosine or the thiols analysed. (AU)