| Author(s): |
Oleskovicz, Nilson
Total Authors: 1
|
| Document type: | Master's Dissertation |
| Press: | Jaboticabal. [2001]. ix, 61 f., gráficos, ilustrações, tabelas. |
| Institution: | Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Faculdade de Ciências Agrárias e Veterinárias |
| Defense date: | 26 set. 2001 |
| Examining board members: |
Valadão, Carlos Augusto Araújo;
Natalini, Claudio Corrêa;
Lauretti, Gabriela Rocha
|
| Advisor: | Valadão, Carlos Augusto Araújo |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine |
| Indexed in: | Banco de Dados Bibliográficos Athena |
| Location: | Universidade Estadual Paulista. Campus de Jaboticabal. Biblioteca da Faculdade de Ciências Agrárias e Veterinárias ; 0141209 |
| Abstract | |
Ketamine, a non-competitive NMDA receptor antagonist, plays a role in inflammatory pain and has been reported to prevent central sensitization, decreasing secondary hyperalgesia after skin incision. Ketamine S(+) was developed recently and has been useful in post-operative pain control in children. The aim of this study was to evaluate the preemptive effect of epidural racemic ketamine (RK) or ketamine S(+) (SK) administration in postincisional pain, in horses. Twenty one mixed breed mares, 6:1:2 years old, weighting 273.2:1:42.0 kg, divided into G1 (n=8), G2 (n=8) and G3 (n=5), were used. An epidural catheter was inserted between the first and the second intereoccygeal space and 15 cm cranially advanced. 24 hours late the thigh region was shaved bilaterally, mechanical cutaneous sensibility was mensured using von Frey filaments (T¬30). Local anaesthesia (6 ml lidocaine 2%, subcutaneously) at the right side (incision side) was performed. The left side was used as control side. Twenty five minutes after lidocaine injection was administred SK in G1 (1.0 mg/kg), RK in G2 (1.0 mg/kg), or saline in G3 through the epidural catheter (diluted with saline to a total volume of 3.4 ml + (BW in kg x 0.013). The aplication time was standardized in 5 minutes... (AU) | |