Ipomoea carnea aqueous fraction intake effects during gestation on physical and neurobehavior development of rats offspring.

Author(s)

Aline Schwarz

• Document type: Master's Dissertation
• Press: São Paulo. , gráficos, ilustrações, tabelas.
• Institution: Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ)
• Defense date: 2002-05-16

Examining board members

Helenice de Souza Spinosa; Regina Lúcia de Moraes Moreau; Ana Cristina Tasaka

• Advisor: Helenice de Souza Spinosa
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Indexed in: Banco de Dados Bibliográficos da USP-DEDALUS; Biblioteca Digital de Teses e Dissertações - USP
• Location: Universidade de São Paulo. Biblioteca do Conjunto das Químicas; CQ T/615.952; S411e

Abstract

Ipomoea carnea, plant Iargely distributed in Brazil, when ingested by animais causes neurotoxic effects. No relates about it\'s effects upon offspring of animais exposed during gestation period appears in the literature. So, in this work, the effects of the exposure of rats, during the gestation period, to the plant were studied. The rats received, by gavage, since the fifth day of gestation, diferent concentrations of the aqueous fraction of the plant (0.7, 3.0 or 15.0 mg/kg/day). The pups were evaluated by physical and reflexological development; when adults, behavior and cerebral neurotransmitters leveis were analised. The results demonstrated that the pups exposed to the higher dose presented high mortality and smaller size at birth. The survivors showed delay in both ears opening and negative geotaxis. No alterations were observed in ali the behaviors evaluated and in the leveis of cerebral neurotransmitters of the animais when adults. This results shows that exposition of rats during gestation to Ipomoea carnea produce some toxic effects in their offspring that don\'t changes the development and the behaviors parameters evaluated in the rats in adult age. (AU)