Effect of cyclosporin A on renal and hepatic functions of normal Golden Retriever dogs or Golden Retriever with muscular dystrophy

Author(s)

Adriana Caroprezo Morini

• Document type: Master's Dissertation
• Press: São Paulo. , gráficos, tabelas.
• Institution: Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD)
• Defense date: 2005-12-09

Examining board members

Maria Angélica Miglino; Carlos Eduardo Ambrosio; Euripedes Ferreira

• Advisor: Maria Angélica Miglino
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Indexed in: Banco de Dados Bibliográficos da USP-DEDALUS; Biblioteca Digital de Teses e Dissertações - USP
• Location: Universidade de São Paulo. Biblioteca da Faculdade de Medicina Veterinária e Zootecnia; FMVZ/T.1598

Abstract

The muscular dystrophy of Golden Retriever (GRMD) is a degenerative miopaty caused by the absence of dystrophy and it is genetically homologue of the Duchenne muscular dystrophy in humans, so, these dogs are considerably experimental models for studies on cellular therapy. Their successful depends of the adequate immunosuppression. Cyclosporin A (CsA) is indicated for that, the monitoring of the blood concentration and adverse effects are essential to viabilise the therapy. It was studied GRMD dogs, and normal dogs from the same breed, submitted for therapy with CsA, associated, on GRMD, of cell transplantation. It was evaluated blood concentration of the drug, and their possible effects on renal and hepatic functions has been considerate the clinic manifestations, urinalisis, blood counts, testis of glomerular function and blood concentrations of urea, cretinine, alanine aminotransferase, alkaline fosfatase, calcium, phosphorus, sodium and potassium. In our results we found a discrete increase of blood urea on booth groups; adverse reactions like vomits, diarrhea, tricose, periodontitis and gingivitis; decrease of blood alanine aminotransferase, increased levels of urine?s cylinders and protein and also increase of urinary density on GRMD group. The CsA blood concentrations oscillated too much on six than eight of our animals. We concluded that more researches wants to be done to evaluated renal functions of GRMD dogs and also that the doses varieties individually and the correct dosage as to important as the evaluation of the blood concentration of the drug and became viable for cell therapy. (AU)