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Mechanisms underlying the anti-hyperalgesic effect of muopioid agonists in the peripheral tissue

Full text
Author(s):
Karla Elena Torres Chavez
Total Authors: 1
Document type: Doctoral Thesis
Press: Piracicaba, SP.
Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba
Defense date:
Examining board members:
Carlos Amílcar Parada; Maria José Rocha Alves; Mariana Trevisani Arthuri Franco; Felippe Bevilacqua Prado; Wander José da Silva
Advisor: Carlos Amílcar Parada
Abstract

The aims of this study were:(1) To verify whether local administration of E2 prostaglandin (PGE2) in peripheral tissue increases the anti-hyperalgesic effect of mu opioid receptor activation and whether this effect is mediated by an increased expression of mu opioid receptor (2) To test if the anti-hyperalgesic effect of the activation of mu opioid receptor in peripheral tissue is associated with the decrease of C-fibers excitability. According to the objective(1)... Note: The complete abstract is available with the full electronic document (AU)

FAPESP's process: 08/02912-9 - Mechanisms underlying the anti-hyperalgesic effect of mu opioid agonists in the peripheral tissue
Grantee:Karla Elena Torres Chávez
Support Opportunities: Scholarships in Brazil - Doctorate