Clinical study of cell-binding peptide (PepGen-P15®) application in advanced periodontal lesions of dogs

Author(s)

Daniel Giberne Ferro

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD)
• Defense date: 2005-08-30

Examining board members

Marco Antonio Gioso; Paulo Eduardo Guedes Carvalho; Moacir Santos de Lacerda

• Advisor: Marco Antonio Gioso

Abstract

The aim of this study was to evaluate the attachment loss, periodontal pocket, gingival ressection and II and III furcation lesion response in teeth after 3 and 6 month with collagen cell-binding peptide (PepGen P-15®) graft application. Twenty one dogs from the FMVZ-USP Veterinary Hospital were anesthetized in order to accomplish periodontal treatment and 91 tooth faces with attachment loss were treated, with 45% (41 faces) receiving PepGen P-15® and 55% (50 faces) constituting the control group that received conventional treatment (muco-gingival flap and root planning). Eight teeth showed furcation lesions. Five received the peptide and three did not. The procedure was documented by radiography and all periodontal probing were photographed. After 3 and 6 month, the animals were re-anesthetized in order to accomplish new photography, radiography and periodontal probing exams. In the furcation exposure of teeth treated with PepGen P-15®, two exhibited reduction of furcation degree, two did not change their conditions and one had the furcation enhanced after 6 month. The conventional treatment group presented one tooth with furcation reduction and no changes in two teeth. The 41 attachment loss faces that received graft material exhibited 40% of regeneration rate after 6 month. The control faces did not change their attachment level. The palatal face presented the better regeneration rates (40%) and the canines and molars teeth showed the better responses (57,14% and 65%, respectively). There was no post-surgical infection related to absence of oral home care. One owner (4,76%) reported daily teeth brushing on his pet. It can be concluded that the PepGen P-15® helps a more rapidly periodontal structure re-attachment and regeneration, including alveolar bone. Its application is easy and practical and the post-surgical complications incidence is low. Nevertheless, more studies and researches are necessary to evaluate the amount and the quality of formed bone and periodontal ligament (AU)