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Development of news technique for reduction of false-positive and automatic definition of parameters of mammograms for CAD schemes

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Author(s):
Ana Cláudia Martinez
Total Authors: 1
Document type: Doctoral Thesis
Press: São Carlos.
Institution: Universidade de São Paulo (USP). Escola de Engenharia de São Carlos (EESC/SBD)
Defense date:
Examining board members:
Homero Schiabel; Antonio Adilton Oliveira Carneiro; Alberto Cliquet Junior; Adilson Gonzaga; Nelson Delfino D'Ávila Mascarenhas
Advisor: Homero Schiabel
Abstract

This present work consists on the investigation of mammographic image characteristics for automatic determination of image processing parameters for a mammography computer aided diagnosis scheme (CAD) in order to get optimal performance. Additionally, using the results obtained on this first investigation, it was also developed a new technique for the reduction of false-positive rates on CAD projects, which can result on the reduction of the number of unnecessary biopsies. For the automatic definition of the image processing parameters for the techniques of detection of microcalcifications and nodules, some image characteristics had been extracted, as standard deviation, third momentum and the thresholding value. Using the proposed automatization method it was reported an increase of 20% in the CAD performance (evaluated determining the ROC curve) in comparison to the non-automatic method (fixed parameter). Besides, for CAD schemes it is necessary to process the entire mammographic image. Thus, it was also developed a technique for automatic selection of regions of interests in the mammogram, which extracts better regions from breast image for further segmentation. False-positives rates was treated by a specific technique based on the comparison of the two typical incidences of mammographic examination that together with the automatic parameter determination method for microcalcification detection produced a significant reduction of 86% of that rate in relation to the procedure that uses fixed parameter. (AU)