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| Author(s): |
Katia Noriko Suzuki
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Pesquisas Energéticas e Nucleares (IPEN/BT) |
| Defense date: | 2009-08-28 |
| Examining board members: |
João Alberto Osso Júnior;
Edson Mendes Boasquevisque;
Ana Maria Graciano Figueiredo;
Haroldo Taurian Gasiglia;
Renata Corrêa Nieto
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| Advisor: | João Alberto Osso Júnior |
| Field of knowledge: | Engineering - Nuclear Engineering |
| Indexed in: | Base de dados PHL Elysio - Rede de Bibliotecas da CNEN; Biblioteca Digital de Teses e Dissertações - USP |
| Location: | Instituto de Pesquisas Energéticas e Nucleares. Biblioteca Terezine Arantes Ferraz |
| Abstract | |
On average 80% of the radiopharmaceuticals used in Nuclear Medicine are labeled with 99mTc due to its physical properties and easy attainment through of 99Mo/99mTc generators. The Directory of Radiopharmacy (DIRF) of IPEN-CNEN/SP developed a gel type chromatographic generator of MoZr with 99Mo produced by 98Mo(n,)99Mo reaction that occurs at the IEA-R1 Nuclear Reactor. The gel is composed of zirconium molibdate with elution volume of 12 mL with an activity of 11100 MBq (300 mCi) producing a radioactive concentration of 925 MBq (25 mCi)/mL. The fission generator gives a higher radioactive concentration around 1850 MBq (50 mCi)/mL. The aim of this work is to study a system of post-elution concentration of 99mTc for the attainment of a high enough radioactive concentration to meet the demands of the market, with a proved quality. Two types of systems of post-elution concentration were developed: the single and the tandem. The most appropriate system for the gel generator of 99Mo/99mTc, being at the same time sterile and vacuum automated, was the tandem system using Dionex 2.5 cc/QMA cartridges. The gel generator is eluted with 10 mL of solution of 0.1% NaCl and the pertechnetate anion is retained in the QMA cartridge and further eluted with 4 mL of saline. The process takes no more than 30 minutes. The elution efficiency of the system of concentration was 90 %. At the beginning of 2009 a global crisis in the supply of 99Mo took place making it necessary the development of alternative technologies for the production of 99Mo/99mTc generators using fission produced 99Mo and the development of an appropriate method to extend the useful life of this generator. The results of this study showed that the same system developed for the post- concentration of the gel generator can be employed for the fission generator, using the tandem system, giving a concentration factor of 3 for the elution of 99mTc. (AU) | |